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J. Thromb. Haemost. · Dec 2016
Inhibition of major integrin αV β3 reduces Staphylococcus aureus attachment to sheared human endothelial cells.
- C J McDonnell, C D Garciarena, R L Watkin, T M McHale, A McLoughlin, J Claes, P Verhamme, P M Cummins, and S W Kerrigan.
- Irish Centre for Vascular Biology, Infection Group, Royal College of Surgeons in Ireland, Dublin, Ireland.
- J. Thromb. Haemost. 2016 Dec 1; 14 (12): 2536-2547.
AbstractEssentials Staphylococcus aureus (S. aureus) binds and impairs function of vascular endothelial cells (EC). We investigated the molecular signals triggered by S. aureus adhesion to EC. Inhibition of the EC integrin αVβ3 reduces S. aureus binding and rescues EC function. αVβ3 blockade represents an attractive target to treat S. aureus bloodborne infections.© 2016 International Society on Thrombosis and Haemostasis.
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