Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Dec 2016
Observational StudyThe long-term recurrence risk of patients with unprovoked venous thromboembolism: an observational cohort study.
Essentials Long-term recurrence risk of venous thromboembolism (VTE) is uncertain. We performed a prospective cohort study of 839 patients with first unprovoked VTE. VTE recurrence risk is high, particularly in men with proximal thrombosis or pulmonary embolism. Sex and VTE site determine the recurrence risk and should be considered for patient counseling.
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J. Thromb. Haemost. · Dec 2016
Lung function, respiratory symptoms and venous thromboembolism risk: the Atherosclerosis Risk in Communities Study.
Essentials The association of lung function with venous thromboembolism (VTE) is unclear. Chronic obstructive pulmonary disease (COPD) patterns were associated with a higher risk of VTE. Symptoms were also associated with a higher risk of VTE, but a restrictive pattern was not. COPD may increase the risk of VTE and respiratory symptoms may be a novel risk marker for VTE.
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J. Thromb. Haemost. · Dec 2016
Inhibition of major integrin αV β3 reduces Staphylococcus aureus attachment to sheared human endothelial cells.
Essentials Staphylococcus aureus (S. aureus) binds and impairs function of vascular endothelial cells (EC). We investigated the molecular signals triggered by S. aureus adhesion to EC. Inhibition of the EC integrin αVβ3 reduces S. aureus binding and rescues EC function. αVβ3 blockade represents an attractive target to treat S. aureus bloodborne infections.