• Pediatric emergency care · Jul 2018

    Case Reports

    Dermatologic Manifestations of Colchicine Intoxication.

    • Asuman Gürkan, Melahat Melek Oğuz, Esin Boduroğlu Cengiz, and Saliha Şenel.
    • From the Departments of Dermatology.
    • Pediatr Emerg Care. 2018 Jul 1; 34 (7): e131-e133.

    AbstractColchicine is an anti-inflammatory drug that has a narrow therapeutic index. Poisoning typically shows 3 phases with systemic symptoms. Gastrointestinal symptoms dominate in the first phase. Dermatologic manifestations usually appear, with skin eruptions in the second phase where multiorgan failure occurs and alopecia in the third phase where organ derangements resolve. Alopecia is a cardinal feature of the third phase, but there is no specifically defined eruption for toxication. Here, we report a case of colchicine intoxication in a 16-year-old girl with maculopapular/purpuric rash and alopecia.

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