• Patrick Leung, David M Dickerson, Sahitya K Denduluri, Maryam K Mohammed, Min Lu, Magdalena Anitescu, and Hue H Luu.
• University of Chicago Medical Center, Department of Orthopaedic Surgery and Rehabilitation, 5841 S. Maryland Ave, M/C 3079, Chicago, IL 60637, United States. Electronic address: Patrick.Leung@uchospitals.edu.
• J Clin Anesth. 2018 Sep 1; 49: 46-52.

Study ObjectiveInvestigate the use of a postoperative continuous adductor canal block (cACB) after epidural analgesia to decreases opioid consumption and improve visual analog scale (VAS) scores compared to a sham catheter.DesignDouble-blinded randomized placebo-controlled trial.SettingInpatient setting in tertiary care teaching hospital with outpatient follow-up.PatientsOne-hundred and sixty-five subjects (cACB n = 82 and sham catheter n = 83) with end-stage degenerative joint disease undergoing elective unilateral total knee arthroplasty.InterventionsPatients were block randomized to receive a cACB or sham catheter. An epidural catheter was placed preoperatively and discontinued on postoperative day 1. Patients then received a cACB with bupivacaine or sham catheter which remained for the duration of the hospitalization.MeasurementsPrimary outcome was total opioid consumption. Secondary outcomes included VAS scores, knee range of motion (ROM), ambulation distance, and WOMAC scores.Main ResultsSeventy patients completed the study (cACB n = 38 and sham catheter n = 32). Compared to sham catheter, in the first 20 h after placement of a cACB, patients used 22.5 mg less opioid (95% CI: -43.1 to -1.94 mg, P = 0.03). VAS score area under the curve decreased 7.8 mm (95% CI: -15.5 - -0.058 mm, P = 0.04) with a cACB. At 3-week follow-up, WOMAC scores were significantly improved with the cACB with a mean difference of 8.72 (95% CI: -17.3 to -0.11, P = 0.04). There were no statistically significant differences in secondary outcomes on postoperative day 2. Paired outcomes at 6 weeks compared to baseline ROM, showed significant improvement in knee ROM with a cACB (mean difference 11.77°, 95% CI: 3.1-20.5°, P = 0.01).ConclusionA postoperative cACB after total knee arthroplasty significantly reduces total opioid consumption and pain scores compared to sham catheter. Ambulatory ability was not affected and patients recovered function earlier. ClinicalTrials.govNCT02121392.Copyright © 2018 Elsevier Inc. All rights reserved.

40 keywords...

hide…