• Michelle Zhang, Line Robitaille, Shaun Eintracht, and L John Hoffer.
• Lady Davis Institute for Medical Research, McGill University, and Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, QC H3T 1E2, Canada. l.hoffer@mcgill.ca
• Nutrition. 2011 May 1; 27 (5): 530-3.

ObjectiveHypovitaminosis C and D are highly prevalent in acutely hospitalized patients, but the clinical significance of these biochemical abnormalities is not known. Because deficiencies of vitamin C and D have been linked to psychologic abnormalities, vitamin C or D provision could improve the mood state of acutely hospitalized patients.MethodsDouble-blind clinical trial of the effect of vitamin C (500 mg twice daily) or vitamin D (1000 IU twice daily) on mood, as assessed with a validated instrument, the Profile of Mood States.ResultsVitamin C therapy increased plasma (P < 0.0001) and mononuclear leukocyte (P = 0.014) vitamin C concentrations and was associated with a 34% reduction in mood disturbance (P = 0.013). Vitamin D therapy increased plasma 25-hydroxyvitamin D concentrations (P = 0.0004), but had no significant effect on mood.ConclusionsTreatment of hypovitaminosis C improves the mood state of acutely hospitalized patients.Copyright © 2011 Elsevier Inc. All rights reserved.

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