• Postgrad Med J · Mar 2005

    Case Reports

    A woman who couldn't speak: report of methotrexate neurotoxicity.

    • P Szawarski and C S Chapman.
    • Glenfield General Hospital, Leicester, UK.
    • Postgrad Med J. 2005 Mar 1; 81 (953): 194-5.

    AbstractThe association between methotrexate therapy and idiosyncratic neurological complications is well recognised in children. This case illustrates the importance of considering the diagnosis of methotrexate toxicity in an adult patient with behavioural and speech disturbances, who received it by intrathecal route only and in whom the only indicator was an abnormal electroencephalographic study.

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