• Chuanyuan Tao, Xin Hu, Jiajing Wang, Junpeng Ma, Hao Li, and Chao You.
• Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
• Biomark Med. 2017 Jan 1; 11 (1): 33-42.

AimInflammation plays a role in secondary brain injury after intracerebral hemorrhage (ICH). We aimed to determine the prognostic significance of admission white blood cell (AWC), neutrophil count (ANC), lymphocyte count, monocyte count and neutrophil to lymphocyte ratio (NLR) for 90-day outcome after ICH.Patients & MethodsA total of 336 patients with spontaneous ICH were retrospectively investigated. Clinical outcome was assessed by modified Rankin Scale at 90 days.ResultsMultivariate analysis showed that higher AWC, ANC, NLR were independently associated with mortality and worse outcome. Moreover, NLR showed a higher predictive ability in mortality than in poor outcome in receiver operating characteristic analysis. Linear regression analyses revealed admission Glasgow Coma Scale score and ICH volume were mostly correlated with these indices.ConclusionElevated levels of AWC, ANC and NLR were independently related to poor 90-day outcome after ICH. NLR may be a novel inflammatory biomarker following ICH.

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