• A&A practice · Apr 2018

    Use of Ketamine in a Multimodal Analgesia Setting for Rapid Opioid Tapering in a Profoundly Opioid-Tolerant Patient: A Case Report.

    • Elise M Strickler, Eric S Schwenk, Mitchell J Cohen, and Eugene R Viscusi.
    • From the Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; and Departments of Anesthesiology and Psychiatry, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.
    • A A Pract. 2018 Apr 1; 10 (7): 179-181.

    AbstractOpioids are frequently used for the treatment of chronic pain, and patients taking high doses are at increased risk of complications and adverse opioid-related events. Ketamine is appealing as an opioid adjunct because of its lack of respiratory depression and potential prevention of hyperalgesia and central sensitization. We present a case in which a ketamine infusion was utilized over a 7-day period to provide rapid taper of a daily dose of 400 mg of morphine equivalents to less than one-third of that dose on discharge with unchanged pain levels and no symptoms of opioid withdrawal.

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