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- Yasuyuki Shimoyama, Kensuke Sugimoto, Mie Kotake, Daisuke Uehara, Yosuke Kamide, Shiko Kuribayashi, Osamu Kawamura, Motoyasu Kusano, Hiroshi Handa, Junko Hirato, and Masanobu Yamada.
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan.
AbstractTwo cases of intravascular lymphoma (IVL) were diagnosed by endoscopic biopsy. Both patients were admitted to our hospital with a fever of an unknown origin. An elevated serum level of soluble interleukin-2 receptor antibody suggested IVL. An upper gastrointestinal endoscopy was performed. A biopsy of both the reddened and normal gastroduodenal mucosa (Case 1) and a biopsy of a gastric antral ulcer, multiple polyploid lesions resembling submucosal tumors in the duodenum, and the patient's normal mucosa (Case 2) revealed vascular infiltration by CD20-positive atypical lymphocytes, confirming the diagnosis of IVL. The performance of a gastrointestinal biopsy for suspected IVL is important, even if there are no visible endoscopic abnormalities.
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