• Osteoporos Int · Dec 2016

    Mice with sclerostin gene deletion are resistant to the severe sublesional bone loss induced by spinal cord injury.

    • W Qin, W Zhao, X Li, Y Peng, L M Harlow, J Li, Y Qin, J Pan, Y Wu, L Ran, H Z Ke, C P Cardozo, and W A Bauman.
    • National Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 130 West Kingsbridge Roa, Bronx, NY, 10468, USA. weiping.qin@mssm.edu.
    • Osteoporos Int. 2016 Dec 1; 27 (12): 3627-3636.

    AbstractBone loss after spinal cord injury (SCI) is rapid, severe, and refractory to interventions studied to date. Mice with sclerostin gene deletion are resistant to the severe sublesional bone loss induced by SCI, further indicating pharmacological inhibition of sclerostin may represent a promising novel approach to this challenging medical problem.

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