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- G Andrew Reid and Sultan Darvesh.
- Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.
- Neuroscience. 2015 Jul 9;298:424-35.
AbstractIn Alzheimer's disease (AD), numerous β-amyloid (Aβ) plaques are associated with butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, containing five human familial AD genes (5XFAD), also develops Aβ plaques with BChE activity. Knock-out of BChE in this model showed diminished fibrillar Aβ plaque deposition, more so in males than females. This suggests that lack of BChE reduces deposition of fibrillar Aβ in AD and this effect may be influenced by sex.Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
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