• Evangeline B Handog, Maria Suzanne L Datuin, and Ivan A Singzon.
• Department of Dermatology, Asian Hospital and Medical Center, Muntinlupa, Metro Manila, Philippines.
• Int. J. Dermatol. 2016 Feb 1; 55 (2): 153-7.

BackgroundGlutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less successful in elevating plasma GSH levels.ObjectivesThe use of a lozenge containing GSH was investigated in order to evaluate the buccal mucosa as a route for GSH administration. Substances that are absorbed through the buccal route go directly into the systemic circulation, effectively bypassing the gastrointestinal tract.MethodsThirty Filipino females with Fitzpatrick skin types IV or V received a glutathione-containing lozenge daily for eight weeks.ResultsFindings showed a significant decrease in melanin indices from baseline to endpoint that became evident in as little as two weeks. There were no serious adverse events, and laboratory examination findings remained normal.ConclusionsThe authors conclude that the lozenge containing glutathione was safe and effective in lightening the skin of Filipino women.© 2015 The International Society of Dermatology.

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