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Case Reports
Tamibarotene for the Treatment of Bronchiolitis Obliterans Associated With Chronic Graft-vs-Host Disease.
- Satoshi Watanabe, Ken Ishiyama, Keigo Saeki, Noriyuki Ohkura, Kazuo Kasahara, and Shinji Nakao.
- Department of Respiratory Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
- Chest. 2019 Jan 1; 155 (1): e1-e4.
AbstractBronchiolitis obliterans (BO) is a significant life-threatening complication that occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and it is associated with increased morbidity and mortality. BO responds poorly to corticosteroids or immunosuppressants, and there are currently no established treatment approaches. We herein describe a patient with biopsy-proven BO after allo-HSCT who was successfully treated with tamibarotene, a novel synthetic retinobenzoic acid. Tamibarotene led to a dramatic improvement in lung function as well as cutaneous manifestations of chronic graft-vs-host disease. A large prospective clinical trial is therefore warranted to confirm the efficacy of tamibarotene in BO.Copyright © 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
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