• Hécio Henrique Araújo de Morais, Jimmy Charles Melo Barbalho, Ricardo José de Holanda Vasconcellos, Fabricio Souza Landim, Fábio Andrey da Costa Araújo, and Tasiana Guedes de Souza Dias.
• Oral and Maxillofacial Department, Dental School of Pernambuco, University of Pernambuco, Av. General Newton Cavalcanti, 1650 Tabatinga, Camaragibe, Pernambuco, 54.756-220, Brazil.
• Oral Maxillofac Surg. 2015 Sep 1; 19 (3): 267-73.

AbstractThe aim of the present study was to compare hemodynamic changes using midazolam 7.5 mg and diazepam 10.0 mg during the surgical removal of symmetrically positioned third molars. A prospective, randomized, double-blind, clinical trial was carried out involving 120 patients divided into three groups: Group 1 (diazepam and placebo), Group 2 (midazolam and placebo), and Group 3 (diazepam and midazolam). Each subject underwent two surgeries on separate occasions under local anesthesia. The following parameters were assessed at five different times (T0, T1, T2, T3, and T4): systolic, diastolic, and mean blood pressure (SBP, DBP, and MBP, respectively); heart rate (HR); oxygen saturation (SpO(2)); rate pressure product (RPP); and pressure rate quotient (PRQ). Statistically significant differences were found regarding heart rate at T2 and T3 (p < 0.005) in Group 2, with a higher rate occurring during midazolam administration. Moreover, significant differences in rate pressure product were found at T2, T3, and T4 in this group, with higher values also occurring during midazolam administration. In Group 3, significant differences in diastolic blood pressure were found at T3 and T4, with higher values occurring during diazepam administration, whereas a higher heart rate occurred at T3 with midazolam. Midazolam 7.5 mg and diazepam 10.0 mg exert an influence on some hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar surgery.

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