• World Neurosurg · Apr 2019

    Isolated antenatal hydrocephalus after foetal exposure to misoprostol : a teratogenic effect of the cytotec® ?

    • Pierre-Aurelien Beuriat, Lucile Cattiaux, Laurent Guibaud, Alexandru Szathmari, Isabelle Sabatier, Christophe Rousselle, Carmine Mottolese, and Federico Di Rocco.
    • Pediatric Neurosurgical Unit, Hôpital Femme Mère Enfant, Claude Bernard University, Lyon, France.
    • World Neurosurg. 2019 Apr 1; 124: 9810098-100.

    BackgroundMisoprostol is often used for termination of pregnancy in France and other countries. However, some pregnancies are continued after taking the drug and congenital malformations are known to be the consequence of fetal exposure to misoprostol, among them hydrocephalus. The type of hydrocephalus in case of misoprostol exposure is not known.Case DescriptionWe report the first case in the literature of an obstructive hydrocephalus due to an aqueduct of Sylvius stenosis diagnosed during pregnancy after misoprostol intake.ConclusionsThe possible physiopathologic implications of the drug regarding the genesis of this malformation are discussed.Copyright © 2019 Elsevier Inc. All rights reserved.

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