• Arthur Carminucci, Matthew Parr, Mireille Bitar, and Shabbar F Danish.
• Department of Neurological Surgery, Rutgers University, New Brunswick, New Jersey, USA.
• World Neurosurg. 2019 Apr 1; 124: 219223219-223.

BackgroundThe majority of complications following (LITT) therapy occur in the early postoperative period, with few long-term complications being reported.Case DescriptionHere we present 2 cases of delayed-onset cyst formation occurring more than 1 year following ablation, a previously unreported complication. In the first case, a 59-year-old female who previously underwent LITT for a radiation-induced cavernoma developed a 2-cm cystic lesion 18 months after ablation, resulting in recurrent seizures. In the second case, a 53-year-old female with a recurrent left frontal cerebral metastasis developed a large cystic lesion 30 months post ablation. Both patients required craniotomies and resection of their cystic lesions. In both cases pathology demonstrated reactive gliosis and blood vessel sclerosis.ConclusionsWe hypothesize chronic gliosis following LITT therapy results in blood vessel sclerosis leading to blood-brain barrier-breakdown and delayed cyst formation. These findings support the need for long-term surveillance of patients treated with LITT.Published by Elsevier Inc.

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