• Ann Pharmacother · Sep 2001

    Review

    Prophylaxis for paclitaxel hypersensitivity reactions.

    • P E Kintzel.
    • Department of Pharmacy, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA. kintzelpe@aol.com
    • Ann Pharmacother. 2001 Sep 1; 35 (9): 1114-7.

    ObjectiveTo evaluate clinical literature supporting the prophylactic use of single-dose intravenous dexamethasone to prevent hypersensitivity reactions (HSRs) to paclitaxel infusion.Data SourcesClinical literature accessed through MEDLINE (from 1986 to 2000).Data SynthesisProphylaxis for paclitaxel-related HSRs generally includes repeated dexamethasone doses beginning 12 hours before paclitaxel, and administration of diphenhydramine plus a histamine2-receptor antagonist 30 minutes before infusion of paclitaxel. Singe-dose intravenous dexamethasone administered with ancillary medications 30 minutes before infusion of paclitaxel has been used to prevent regimen-related HSRs.ConclusionsSingle-dose intravenous dexamethasone can be used in combination with appropriate ancillary medications to prevent paclitaxel-related HSRs.

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