• Neuroscience · Oct 2014

    Review

    The role of inhibition in human motor cortical plasticity.

    • V Bachtiar and C J Stagg.
    • Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
    • Neuroscience. 2014 Oct 10; 278: 93-104.

    AbstractOver recent years evidence from animal studies strongly suggests that a decrease in local inhibitory signaling is necessary for synaptic plasticity to occur. However, the role of GABAergic modulation in human motor plasticity is less well understood. Here, we summarize the techniques available to quantify GABA in humans, before reviewing the existing evidence for the role of inhibitory signaling in human motor plasticity. We discuss a number of important outstanding questions that remain before the role of GABAergic modulation in long-term plasticity in humans, such as that underpinning recovery after stroke, can be established. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

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