• Claudia Yaneth Rodríguez-Triviño, Isidro Torres Castro, and Zulma Dueñas.
• Departamento de Ciencias Fisiológicas, Grupo Navarra Medicina, Facultad de Ciencias de la Salud, Fundación Universitaria Navarra-UNINAVARRA, Neiva, Huila, Colombia; Departamento de Ciencias Fisiológicas, Grupo de Neurobiología y Comportamiento, Facultad de Medicina, Universidad Nacional de Colombia, Sede Bogotá, Bogotá D.C., Colombia. Electronic address: clausr3@gmail.com.
• World Neurosurg. 2019 Apr 1; 124: e783e788e783-e788.

ObjectiveTo determine association between electrolyte disturbances and mortality in patients with severe traumatic brain injury.MethodsMedical records of patients with severe traumatic brain injury and Glasgow Coma Scale score <8 and electrolyte alterations were reviewed in a retrospective cohort study. Electrolyte levels were analyzed to establish an association between patients who died and patients who survived. Bivariate analysis was performed using χ2 test with a statistical reliability of 95% for categorical variables. Analysis for electrolyte changes to determine association with mortality was performed using χ2 test with multiple comparisons. Logistic regression was performed between the electrolyte alterations and their association with mortality. The reliability of statistical tests was 95%.ResultsThere was a significant relationship between hypochloremia and increased risk of mortality in 23.1% of deceased patients (P = 0.03). Furthermore, there was a significant correlation with age (P < 0.01) and with the Acute Physiology and Chronic Health Evaluation APACHE II (P < 0.01).ConclusionsHypochloremia could be an important prognostic factor to determine mortality risk and to improve treatment in patients with severe traumatic brain injury.Copyright © 2019 Elsevier Inc. All rights reserved.

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