• Neuroscience · Oct 2014

    Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury.

    • M Sasaki, S Hashimoto, T Sawa, and F Amaya.
    • Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    • Neuroscience. 2014 Oct 24;279:1-9.

    AbstractCCAAT/enhancer binding protein-beta (C/EBP-beta) is a transcription factor that belongs to the C/EBP family. To understand the role of C/EBP-beta in the peripheral nervous system, we investigated the expression of C/EBP-beta in the dorsal root ganglion. C/EBP-beta was weakly detected in nuclei of naive dorsal root ganglion (DRG) neurons. Spinal nerve ligation increased the expression of C/EBP-beta in L4 and L5 DRG neurons. Treatment with anti-TNF-alpha prevented SNL-induced pain hypersensitivity and C/EBP-beta expression in the DRG. Injection of TNF-alpha into the sciatic nerve produced transient pain hypersensitivity and induction of C/EBP-beta expression in the DRG. These results demonstrate that C/EBP-beta is activated in the DRG neurons by a TNF-alpha-dependent manner and might be involved in the activation of primary afferent neurons after nerve injury.Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

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