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Review
Development of novel antigen receptors for CAR T-cell therapy directed toward solid malignancies.
- David Chen and James Yang.
- Surgery Branch, National Cancer Institute National Institutes of Health, Bethesda, Md. Electronic address: david.chen4@nih.gov.
- Transl Res. 2017 Sep 1; 187: 11-21.
AbstractDevelopment of chimeric antigen receptor (CAR) T cells have led to remarkable successes in the treatment of B-cell malignancies with anti-CD19 CAR. Here we discuss the development of novel antigen receptors for use in solid malignancies with respect to target antigens, receptor design, and T cell manipulations.Published by Elsevier Inc.
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