• Daisuke Wajima, Fumiya Sato, Kenya Kawamura, Keisuke Sugiura, Ichiro Nakagawa, Yasushi Motoyama, Young-Soo Park, and Hiroyuki Nakase.
• Department of Neurosurgery, Nara Medical University, Japan. Electronic address: wajima@naramed-u.ac.jp.
• Brain Res. 2017 Sep 1; 1670: 165-172.

AbstractAcute subdural hematoma (ASDH) is a frequent complication of severe head injury, whose secondary ischemic lesions are often responsible for the severity of the disease. We focused on the differences of secondary ischemic lesions caused by the components, 0.4ml venous- or arterial-blood, or saline, infused in the subdural space, evaluating the differences in vivo model, using rats. The saline infused rats are made for elderly atrophic brain with subdural effusion (SDE) model. Our data showed that subdural blood, both venous- and arterial-blood, aggravate brain edema and lesion development more than SDE. This study is the first study, in which different fluids in rats' subdural space, ASDH or SDE are compared with the extension of early and delayed brain damage by measuring brain edema and histological lesion volume. Blood constituents started to affect the degree of ischemia underneath the subdural hemorrhage, leading to more pronounced breakdown of the blood-brain barrier and brain damage. This indicates that further strategies to treat blood-dependent effects more efficiently are in view for patients with ASDH.Copyright © 2017 Elsevier B.V. All rights reserved.

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