• Clin Neuropharmacol · Jul 2008

    Case Reports

    Late-life somnambulism after therapy with metoprolol.

    • Jutta Hensel and Frank Pillmann.
    • Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany.
    • Clin Neuropharmacol. 2008 Jul 1; 31 (4): 248-50.

    AbstractWe present a case involving a 66-year-old woman with a history of childhood somnambulism who presented with a recent recurrence of sleepwalking. The diagnosis of somnambulism was confirmed polysomnographically and linked etiologically to the start of using metoprolol, a lipophilic beta-blocker, for treating her hypertension. The parasomnia disappeared completely after discontinuation of the drug. Recurrence of non-REM parasomnias, such as somnambulism, has previously been described as an adverse effect of the beta-blocker, propranolol, solely in patients with migraine. There was no history of migraine in the patient presented here. The clinical significance of the findings and possible underlying mechanisms are discussed.

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