Clinical neuropharmacology
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Clin Neuropharmacol · Jul 2008
Case ReportsRemission of migraine attacks in a patient with depression who is taking pregabalin.
Antiepileptic drugs (AED) are increasingly used in the treatment of migraine. Pregabalin (PGB) is an AED that has been used in the treatment of partial seizures, of various types of pain, and of certain anxiety disorders, but to the best of our knowledge, there has been no report on the use of PGB in the treatment of migraine. ⋯ The PGB mechanism of action in conjunction with its structural similarity with gabapentin, already successfully tested in the treatment of migraine, provide additional supportive evidence, theoretical and clinical, respectively, for PGB potential to alleviate migraine symptoms. However, only carefully randomized, controlled studies, or at the very least, open-label series of large patient samples treated in a similar fashion could establish the efficacy of PGB in migraine treatment.
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We present a case involving a 66-year-old woman with a history of childhood somnambulism who presented with a recent recurrence of sleepwalking. The diagnosis of somnambulism was confirmed polysomnographically and linked etiologically to the start of using metoprolol, a lipophilic beta-blocker, for treating her hypertension. ⋯ There was no history of migraine in the patient presented here. The clinical significance of the findings and possible underlying mechanisms are discussed.