• Neuroscience · Dec 2014

    Review

    The place of dopamine in the cortico-basal ganglia circuit.

    • S N Haber.
    • Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, United States. Electronic address: suzanne_haber@urmc.rochester.edu.
    • Neuroscience. 2014 Dec 12; 282: 248-57.

    AbstractThe midbrain dopamine (DA) neurons play a central role in developing appropriate goal-directed behaviors, including the motivation and cognition to develop appropriate actions to obtain a specific outcome. Indeed, subpopulations of DA neurons have been associated with these different functions: the mesolimbic, mesocortical, and nigrostriatal pathways. The mesolimbic and nigrostriatal pathways are an integral part of the basal ganglia through its reciprocal connections to the ventral and dorsal striatum respectively. This chapter reviews the connections of the midbrain DA cells and their role in integrating information across limbic, cognitive and motor functions. Emphasis is placed on the interface between these functional domains within the striatum through corticostriatal connections, through the striato-nigro-striatal connection, and through the lateral habenula projection to the midbrain. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

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