• Clin Otolaryngol Allied Sci · Dec 1991

    Randomized Controlled Trial Clinical Trial

    Analgesia in tonsillectomy: a double-blind study on pre and post-operative treatment with diclofenac.

    • I Nordbladh, B Ohlander, and R Björkman.
    • ENT Department, Växjö Central Hospital, Sweden.
    • Clin Otolaryngol Allied Sci. 1991 Dec 1; 16 (6): 554-8.

    AbstractThe efficacy and tolerability of diclofenac suppositories given pre and/or post-operatively were investigated in a randomized double-blind study on 99 patients undergoing tonsillectomy. In one group, 50 mg diclofenac was given 1 h preoperatively, followed by 50 mg directly after the operation. In another group, diclofenac 100 mg was given only immediately post-operatively. A significantly lower consumption of rescue analgesics (paracetamol and/or pethidine) was found in the group treated preoperatively with diclofenac and the average time until first demand of rescue analgesics was significantly longer compared to the group given diclofenac post-operatively only. The tolerance was good and no serious bleeding complications occurred in either group. In the treatment of post-operative pain after tonsillectomy, the combination of pre and post-operative administration of diclofenac suppositories resulted in significantly lower consumption of rescue analgesics and is thus preferable to administration solely post-operatively.

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