• Simone Holzer, Denise de Oliveira Schoeps, Fabiola Isabel Suano-Souza, Anelise Del Vecchio Gessulo, Sonia Hix, Fonseca Fernando Luiz Affonso FLA Laboratory of Clinical Analysis, Pharmaceutical Sciences and Management in Environmental Health, Faculdade de Medicina do ABC, Santo And, and Sarni Roseli Oselka Saccardo ROS Department of Pediatrics, Faculdade de Medicina do ABC, Santo Andre, Brazil; Department of Pediatrics, Federal University of São Paulo-Es.
• Department of Pediatrics, Faculdade de Medicina do ABC, Santo Andre, Brazil.
• Nutrition. 2019 Jun 1; 62: 20-24.

ObjectivesThe objective of this study was to evaluate estimated glomerular filtration rates (eGFR) and markers of renal function in very low birthweight (VLBW) children and to relate these parameters to current nutritional status.MethodsA cross-sectional and controlled study was performed with prepubertal children between ages 5 and 10, including 44 VLBW participants and 30 healthy participants born at full term with an adequate birthweight (control group). The following data were collected: perinatal history; current weight, height and waist circumference; blood pressure (three measures); blood creatinine, urea, uric acid, cystatin-C, and neutrophil gelatinase-associated lipocalin levels; and urine albumin, creatinine, and calcium levels.ResultsBlood pressure, eGFR, albuminuria, concentrations of cystatin-C, neutrophil gelatinase-associated lipocalin, uric acid, urea, creatinine, and fractional calcium excretion did not differ between VLBW and control groups. Regarding the VLBW group, there was no difference in eGFR, albuminuria, and other markers of renal injury in overweight or obese children compared with children with a normal body mass index.ConclusionsPrepubertal children born with VLBW did not have altered renal function, regardless of their current nutritional status.Copyright © 2018 Elsevier Inc. All rights reserved.

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