• Cécile Bétry, Madeleine Lauverjat, Thomas Mouillot, Charlotte Bergoin, Didier Barnoud, Sabrina Ait, and Cécile Chambrier.
• The Medical School, University of Nottingham, Nottingham, UK; Unité de nutrition clinique intensive, Hospices Civils de Lyon, Lyon, France. Electronic address: cbetry@chu-grenoble.fr.
• Nutrition. 2019 Jun 1; 62: 146-151.

ObjectivesSome patients with short bowel syndrome (SBS) develop hyperphagic behavior. Such an increase in food intake stimulates intestinal adaptation and limits dependence on parenteral nutrition (PN). The aim of this study was to determine the factors modulating food consumption in patients with SBS.MethodsThe associations between oral energy intake (OEI) and anthropometric, metabolic, nutritional, and intestinal absorption-related characteristics were determined in a monocentric cohort of patients with SBS on PN with a stable nutritional status. Body composition was assessed by dual x-ray absorptiometry. Data were retrospectively collected from clinical records.ResultsAfter screening, 38 adult patients with a SBS on PN were included in this study. OEI ranged from 577 to 4054kcal/d. OEI correlated positively with weight, fat-free mass, handgrip strength, and resting energy expenditure (REE) and negatively with free triiodothyronine and C-reactive protein using Spearman correlation. Fat-free mass and thyroid-stimulating hormone remained positively correlated with OEI independently of all other parameters in a multilinear regression model.ConclusionsFat-free mass is a strong predictor of OEI in patients with SBS on PN and without debilitating gastrointestinal symptoms. Increasing fat-free mass could be a way to stimulate OEI in these patients. Further studies are needed to assess this assumption.Copyright © 2018 Elsevier Inc. All rights reserved.

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