• J. Neurol. Neurosurg. Psychiatr. · May 2004

    Imidazoline I(2) receptor density increases with the malignancy of human gliomas.

    • L F Callado, J I Martín-Gómez, J Ruiz, J M Garibi, and J J Meana.
    • Department of Pharmacology, University of the Basque Country, E-48940 Leioa, Spain. kfbcahel@lg.ehu.es
    • J. Neurol. Neurosurg. Psychiatr. 2004 May 1; 75 (5): 785-7.

    BackgroundCurrent glioma grading schemes are limited by subjective histological criteria. Imidazoline I(2) receptors are principally expressed on glial cells.ObjectiveTo investigate the feasibility of using the measurement of imidazoline I(2) receptor expression to differentiate glial tumours from other types of brain tumours and for grading the different gliomas.MethodsThe specific binding of [(3)H]idazoxan to imidazoline I(2) receptors was measured in homogenates from human gliomas of different grades.ResultsThe density of imidazoline I(2) receptors was significantly greater in the three types of malignant glial tumours than in postmortem control brain or non-glial tumours. The increase in density correlated with the malignancy grade of the gliomas. No significant differences in affinity values were observed.ConclusionThese results suggest that the density of imidazoline I(2) receptors may be a useful radioligand parameter for the differentiation of glial tumours from other types of brain tumours and for grading the different gliomas.

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