• J. Neurol. Neurosurg. Psychiatr. · Jul 2004

    Meta Analysis

    Tau gene and Parkinson's disease: a case-control study and meta-analysis.

    • D G Healy, P M Abou-Sleiman, A J Lees, J P Casas, N Quinn, K Bhatia, A D Hingorani, and N W Wood.
    • Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK.
    • J. Neurol. Neurosurg. Psychiatr. 2004 Jul 1; 75 (7): 962-5.

    ObjectiveTo investigate whether the tau H1 haplotype is a genetic risk factor in Parkinson's disease and to report a meta-analysis on all previously published dataMethodsand results: In a sample of 580 patients with Parkinson's disease and 513 controls there was an increased risk of Parkinson's disease for both the tau H1 haplotype (pConclusionsHomozygosity for the tau H1 is associated with an increased risk of Parkinson's disease. This adds to the growing body of evidence that common genetic variation contributes to the pathogenesis of this disorder.

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