• Am. J. Physiol. · Nov 1989

    Calcium-channel blockade in canine hemorrhagic shock.

    • J W Horton.
    • Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, 75235-9031.
    • Am. J. Physiol. 1989 Nov 1; 257 (5 Pt 2): R1012-9.

    AbstractThe effect of verapamil (VER) resuscitation from shock on cardiac function, regional blood flow, as well as skeletal muscle transmembrane potential (TMP) and electrolyte redistribution were studied. Two hours of hypotensive shock in the dog significantly impaired cardiac function and coronary perfusion; TMP fell from 89.9 +/- 0.9 to 75.1 +/- 1.2 mV. Skeletal muscle (SMS) extracellular water decreased 40 +/- 2%, whereas intracellular sodium and chloride increased and intracellular potassium fell. Serum hypocalcemia was accompanied by a significant rise in total myocardial tissue calcium (from 312 +/- 20 to 415 +/- 21 micrograms/g dry wt; P = 0.01); total SMS tissue calcium tended to increase during this time (from 259 +/- 24 to 305 +/- 46 micrograms/g dry wt). After 2 h of shock, all dogs received shed blood and lactated Ringer solution (60 ml/kg); 21 dogs received VER, 20 micrograms/kg with fluid resuscitation; 21 dogs received fluid resuscitation only. Volume replacement improved hemodynamic function to a similar extent in all dogs. However, TMP, intracellular water, sodium, and potassium returned closer to base-line values after VER compared with dogs given only fluid resuscitation. SMS calcium was lower in VER dogs (148 +/- 4 micrograms/g) compared with dogs treated with fluid alone (322 +/- 24 micrograms/g, P = 0.01). Myocardial calcium fell in all dogs after volume replacement regardless of calcium-channel blockade (VER: 148 +/- 8, Ringer: 165 +/- 17 micrograms/g; P greater than 0.05). Our data indicate a potential role for calcium-entry blockade in the treatment of hemorrhagic shock.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.