• B Geffin and L Shapiro.
• Department of Anesthesiology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135-2997, USA.
• J Clin Anesth. 1998 Jun 1; 10 (4): 278-85.

Study ObjectiveTo characterize the clinical features that predispose to sinus bradycardia and cardiac arrest during spinal and epidural anesthesia.DesignRetrospective clinical review.SettingUniversity affiliated medical center.Patients13 patients, aged 26 to 76 years, who suffered severe sinus bradycardia or asystole over a 5-year period, during which approximately 4,000 regional anesthetics were administered.Measurements And Main ResultsCase histories of 13 patients who developed severe sinus bradycardia or asystole during spinal or epidural anesthesia are summarized. Twelve cases occurred during spinal anesthesia, and the thirteenth, during epidural anesthesia. In all but one case, the acute event occurred 15 minutes or longer from the time of the anesthetic injection. Resuscitation was successful in all cases, with no postoperative sequelae.ConclusionThe clinical picture suggests a reflex cause, possibly associated with low right-sided cardiac filling pressure. No common precipitating cause or high-risk patient profile was noted.

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