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- Masaru Enomoto, Akihiro Tamori, and Norifumi Kawada.
- Department of Hepatology, Osaka City University Medical School, Osaka, Japan.
- Rev Recent Clin Trials. 2009 Sep 1; 4 (3): 179-84.
AbstractInfection with hepatitis C virus (HCV) is a global health problem that affects approximately 170 million people worldwide. The current standard therapy with peginterferon alpha plus ribavirin for 48 weeks results in a sustained virologic response in less than 50% of patients with chronic hepatitis C genotype 1--the most prevalent type of HCV in North America and Europe. Development of new antiviral medicines has been hampered by the lack of an effective cell culture system and small-animal model. Herein we review recent progress in the development of new treatments under investigation in clinical trials, including specifically targeted antiviral therapy for HCV such as NS3/4A protease and NS5B polymerase inhibitors.
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