• Frédéric Faugeras, Benjamin Rohaut, Mélanie Valente, Jacobo Sitt, Sophie Demeret, Francis Bolgert, Nicolas Weiss, Alexandra Grinea, Clémence Marois, Marion Quirins, Athena Demertzi, Federico Raimondo, Damien Galanaud, Marie-Odile Habert, Denis Engemann, Louis Puybasset, and Lionel Naccache.
• a AP-HP, Groupe hospitalier Pitié-Salpêtrière , Department of Neurology , Paris , France.
• Brain Inj. 2018 Jan 1; 32 (1): 72-77.

BackgroundThe prognosis value of early clinical diagnosis of consciousness impairment is documented by an extremely limited number of studies, whereas it may convey important information to guide medical decisions.ObjectiveWe aimed at determining if patients diagnosed at an early stage (<90 days after brain injury) as being in the minimally conscious state (MCS) have a better prognosis than patients in the vegetative state/Unresponsive Wakefulness syndrome (VS/UWS), independent of care limitations or withdrawal decisions.MethodsPatients hospitalized in ICUs of the Pitié-Salpêtrière Hospital (Paris, France) from November 2008 to January 2011 were included and evaluated behaviourally with standardized assessment and with the Coma Recovery Scale-Revised as being either in the VS/UWS or in the MCS. They were then prospectively followed until 1July 2011 to evaluate their outcome with the GOSE. We compared survival function and outcomes of these two groups.ResultsBoth survival function and outcomes, including consciousness recovery, were significantly better in the MCS group. This difference of outcome still holds when considering only patients still alive at the end of the study.ConclusionsEarly accurate clinical diagnosis of VS/UWS or MCS conveys a strong prognostic value of survival and of consciousness recovery.

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