• Craig A Solem, Edward V Loftus, Joel G Fletcher, Todd H Baron, Christopher J Gostout, Bret T Petersen, William J Tremaine, Laurence J Egan, William A Faubion, Kenneth W Schroeder, Darrell S Pardi, Karen A Hanson, Debra A Jewell, John M Barlow, Jeff L Fidler, James E Huprich, C Daniel Johnson, W Scott Harmsen, Alan R Zinsmeister, and William J Sandborn.
• Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
• Gastrointest. Endosc. 2008 Aug 1; 68 (2): 255-66.

BackgroundWith the introduction of new techniques to image the small bowel, there remains uncertainty about their role for diagnosing Crohn's disease.ObjectiveTo assess the sensitivity and specificity of capsule endoscopy (CE), CT enterography (CTE), ileocolonoscopy, and small-bowel follow-through (SBFT) in the diagnosis of small bowel Crohn's disease.MethodsProspective, blinded trial.SettingInflammatory bowel disease clinic at an academic medical center.PatientsKnown or suspected Crohn's disease. Exclusion criteria included known abdominal abscess and non-steroidal anti-inflammatory drug (NSAID) use. Partial small-bowel obstruction (PSBO) at CTE excluded patients from subsequent CE.InterventionsPatients underwent all 4 tests over a 4-day period.Main Outcome MeasurementsSensitivity, specificity, and accuracy of each test to detect active small-bowel Crohn's disease. The criterion standard was a consensus diagnosis based upon clinical presentation and all 4 studies.ResultsForty-one CTE examinations were performed. Seven patients (17%) had an asymptomatic PSBO. Forty patients underwent colonoscopy, 38 had SBFT studies, and 28 had CE examinations. Small-bowel Crohn's disease was active in 51%, absent in 42%, inactive in 5%, and suspicious in 2% of patients. The sensitivity of CE for detecting active small-bowel Crohn's disease was 83%, not significantly higher than CTE (83%), ileocolonoscopy (74%), or SBFT (65%). However, the specificity of CE (53%) was significantly lower than the other tests (P < .05). One patient developed a transient PSBO due to CE, but no patients had retained capsules.LimitationUse of a consensus clinical diagnosis as the criterion standard-but this is how Crohn's disease is diagnosed in practice.ConclusionsThe sensitivity of CE for active small-bowel Crohn's disease was not significantly different from CTE, ileocolonoscopy, or SBFT. However, lower specificity and the need for preceding small-bowel radiography (due to the high frequency of asymptomatic PSBO) may limit the utility of CE as a first-line test for Crohn's disease.

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