• AJNR Am J Neuroradiol · Aug 2012

    Case Reports

    Atypical diffusion-restricted lesion in 5-Fluorouracil encephalopathy.

    • W-W Lee, J-S Kim, K R Son, and H-M Kwon.
    • Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
    • AJNR Am J Neuroradiol. 2012 Aug 1; 33 (7): E102-3.

    AbstractCentral nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging.

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