• Hematol. Oncol. Clin. North Am. · Feb 2018

    Review

    Unicentric Castleman Disease.

    • Wong Raymond S M RSM Department of Medicine and Therapeutics, Sir Y.K. Pao Cancer Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing .
    • Department of Medicine and Therapeutics, Sir Y.K. Pao Cancer Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong. Electronic address: raymondwong@cuhk.edu.hk.
    • Hematol. Oncol. Clin. North Am. 2018 Feb 1; 32 (1): 65-73.

    AbstractUnicentric Castleman disease (UCD) is a rare lymphoproliferative disorder that manifests typically as proliferation of a single lymph node or region of lymph nodes. Histologically, hyaline vascular variant is found in a majority of UCDs. UCD commonly presents in younger patient populations. Patients with UCD may be asymptomatic or present with symptoms related to mass effects on surrounding structures. It is difficult to achieve a definitive diagnosis by imaging alone. Histologic examination of the lesion remains the gold standard for diagnosis. Complete surgical resection is the best primary treatment modality for UCD resulting in excellent long-term survival and low recurrence rates.Copyright © 2017 Elsevier Inc. All rights reserved.

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