• Priscila Vaz de Melo Ribeiro, Patrícia Amaro Andrade, Helen Hermana Miranda Hermsdorff, Carolina Araújo Dos Santos, Rosângela Minardi Mitre Cotta, Estanislau Juliana de Assis Silva Gomes JASG Laboratório Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Fed, Aline Aparecida de Oliveira Campos, and Carla de Oliveira Barbosa Rosa.
• Department of Nutrition and Health, Universidade Federal de Viçosa, Minas Gerais, Brazil. Electronic address: Priscilavazdemelo@yahoo.com.br.
• Nutrition. 2019 Oct 1; 66: 22-28.

AbstractAmong the 10 leading causes of death in developed countries are chronic non-communicable diseases (NCDs). The effect of these multifactorial diseases on public health has stimulated considerable research aimed at investigating their primary risk factors (genetic factors, stress, food intake, and amount of physical exercise). Thus, healthful foods (e.g., fruits, vegetables, oils, grains, and seeds) are sources of bioactive compounds that promote good health and disease prevention. Among their components are non-caloric substances identified as non-nutrients (polyphenols, phytosterols, saponins, and phytates), which have been found to have a role in modulating metabolic pathways, maintaining health, and preventing NCDs. The aim of this study is to demonstrate and review the performance of some non-nutrients, such as their antioxidant and anti-inflammatory action, modulation of the antiatherogenic lipid profile (higher high-density lipoprotein cholesterol, lower oxidized low-density lipoprotein, and triacylglycerols), reduction of glucose and fat intestinal absorption, increase in insulin sensitivity, and stimulation of nitic oxide synthesis.Copyright © 2019 Elsevier Inc. All rights reserved.

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