• Ikuko Kashino, Mauro Serafini, Kayo Kurotani, Shamima Akter, Tetsuya Mizoue, Junko Ishihara, Ayaka Kotemori, Norie Sawada, Manami Inoue, Motoki Iwasaki, Mitsushiko Noda, Shoichiro Tsugane, and Japan Public Health Center-based Prospective Study Group.
• Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: ikukokashino@gmail.com.
• Nutrition. 2019 Oct 1; 66: 62-69.

ObjectiveIntake of antioxidants may reduce the risk for type 2 diabetes (T2D) by reducing oxidative stress. However, it is unclear whether dietary non-enzymatic antioxidant capacity (NEAC), which represents the cumulative action of dietary antioxidants and their synergistic effects in foods, is associated with decreased T2D risk. The aim of this study was to investigate the associations between dietary NEAC and T2D.MethodsThe study included 64 660 adults (27 809 men and 36 851 women), 44 to 76 y of age without history of T2D in the Japan Public Health Center-based Prospective Study. Dietary NEAC was estimated using databases of NEAC measurements compiled from results for three different assays: ferric reducing-antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and total radical-trapping antioxidant parameter (TRAP). A multiple logistic regression model was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of self-reported physician-diagnosed T2D over 5 y with adjustment for potential confounders.ResultsIn all, 1191 cases of newly diagnosed T2D were reported. Dietary NEACs were not significantly associated with T2D. The multivariate-adjusted ORs were 1.04 (95% CI, 0.88-1.23; Ptrend = 0.56) for FRAP, 1.11 (95% CI, 0.93-1.32; Ptrend = 0.26) for ORAC, and 0.99 (95% CI, 0.84-1.18; Ptrend = 0.84) for TRAP. Similar associations were observed in men and women (Pinteraction = 0.46 for FRAP, 0.35 for ORAC, and 0.63 for TRAP). In stratified analyses of major prooxidant factors, no notable associations with smoking and obesity status were observed.ConclusionsThis finding suggests that dietary NEAC may not be appreciably associated with T2D in Japanese adults.Copyright © 2019. Published by Elsevier Inc.

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