• Nihon Shokakibyo Gakkai Zasshi · Apr 2016

    Case Reports

    [A case of a gastrointestinal stromal tumor of the rectum effectively treated with continuously-administered regorafenib after failure of imatinib and sunitinib].

    • Shinya Kajiura, Ayumu Hosokawa, Sohachi Nanjyo, Naokatsu Nakada, Takayuki Ando, and Toshiro Sugiyama.
    • Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama.
    • Nihon Shokakibyo Gakkai Zasshi. 2016 Apr 1; 113 (4): 655-61.

    AbstractRegorafenib is recommended as a third-line treatment for unresectable gastrointestinal stromal tumors (GIST). It is usually administered in a repeating cycle of three-weeks on and one-week off. We describe a patient with an unresectable GIST in the pelvic cavity who complained of pelvic pain while taking the one-week break from regorafenib administration. Subsequently, we reduced the dosage to one level and regorafenib was continuously administered. As a result, the adverse events were improved and the antitumor effect against the GIST was retained. The continuous administration of reduced-dose regorafenib could be considered a viable dosage adjustment in specific situations.

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