• P H Schoch, A Ranno, and D S North.
• Denver Department of Veterans Affairs (VA) Medical Center, CO.
• Ann Pharmacother. 1992 Oct 1; 26 (10): 1233-6.

ObjectiveTo report a case of ketorolac tromethamine-induced acute renal failure and to discuss the risk factors that make patients more susceptible to the renal effects of nonsteroidal antiinflammatory drugs (NSAIDs).Data SourcesCase reports and review articles identified by MEDLINE. Indexing terms included ketorolac, renal failure, and NSAIDs.Data ExtractionData were abstracted from pertinent published English-language sources and were reviewed by all authors.Data SynthesisKetorolac is an intramuscularly administered NSAID with many of the same adverse effects associated with other oral NSAIDs. Although reversible depression of renal function has been associated with several NSAIDs, to date there have been no published reports of acute renal failure secondary to ketorolac administration. A 71-year-old woman received three doses of ketorolac to control the pain associated with pelvic and T11-T12 compression fractures. Over the next two days, the patient developed signs and symptoms of acute renal failure, including significant increases in blood urea nitrogen, serum creatinine, and peripheral edema. These signs and symptoms resolved over the next three to four days. Certain risk factors, several of which were present in this woman, make individual patients more susceptible to the renal affects of NSAIDs. These risk factors include advanced age, cirrhosis, volume depletion, congestive heart failure, gastrointestinal bleeding, and preexisting mild renal dysfunction.ConclusionsCaution should be taken when initiating ketorolac or any NSAID therapy with specific attention to risk factors that predispose a patient to renal dysfunction.

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