• Med. J. Aust. · Sep 2018

    Observational Study

    Coordinated care for patients with cirrhosis: fewer liver-related emergency admissions and improved survival.

    • Jeyamani Ramachandran, Monowar Hossain, Chris Hrycek, Edmund Tse, Kate R Muller, Richard J Woodman, Billingsley Kaambwa, and Alan J Wigg.
    • Flinders Medical Centre, Adelaide, SA jeyamani.ramachandran@sa.gov.au.
    • Med. J. Aust. 2018 Sep 1; 209 (7): 301-305.

    ObjectivesTo compare the incidence of liver-related emergency admissions and survival of patients after hospitalisation for decompensated cirrhosis at two major hospitals, one applying a coordinated chronic disease management model (U1), the other standard care (U2); to examine predictors of mortality for these patients.DesignRetrospective observational cohort study.SettingTwo major tertiary hospitals in an Australian capital city.ParticipantsPatients admitted with a diagnosis of decompensated cirrhosis during October 2013 - October 2014, identified on the basis of International Classification of Diseases (ICD-10) codes.Main Outcome MeasuresIncident rates of liver-related emergency admissions; survival (to 3 years).ResultsSixty-nine patients from U1 and 54 from U2 were eligible for inclusion; the median follow-up time was 530 days (range, 21-1105 days). The incidence of liver-related emergency admissions was lower for U1 (mean, 1.14 admissions per person-year; 95% CI, 0.95-1.36) than for U2 (mean, 1.55 admissions per person-year; 95% CI, 1.28-1.85; adjusted incidence rate ratio [U1 v U2], 0.52; 95% CI, 0.28-0.98; P = 0.042). The adjusted probabilities of transplantation-free survival at 3 years were 67.7% (U1) and 37.2% (U2) (P = 0.009). Independent predictors of reduced transplantation-free free survival were Charlson comorbidity index score (per point: hazard ratio [HR], 1.27; 95% CI, 1.05-1.54, P = 0.014), liver-related emergency admissions within 90 days of discharge (HR, 3.60; 95% CI, 1.87-6.92; P < 0.001), and unit (U2 v U1: HR, 2.54, 95% CI, 1.26-5.09; P = 0.009).ConclusionsA coordinated care model for managing patients with decompensated cirrhosis was associated with improved survival and fewer liver-related emergency admissions than standard care.

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