• Shahryar Sane, Mohammadamin Valizadeh Hasanlui, Rahman Abbasivash, Alireza Mahoori, Seyed Taghi Hashemi, and Fahime Rafiei.
• Department of Anesthesiology, Imam Khomeini Hospital, Urmia, Iran.
• Adv Biomed Res. 2015 Jan 1; 4: 230.

BackgroundNausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of postdelivery intra- and post-operative nausea and vomiting during CS under spinal anesthesia.Materials And MethodsA randomized, prospective, double-blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. The patients received 4 mg ondansetron in Group O, 8 mg dexamethasone in Group D, and 4 mg ondansetron +8 mg dexamethasone in Group OD intravenously within 1-2 min after the umbilical cord was clamped. Frequency of postdelivery intra- and post-operative nausea and vomiting episodes was recorded.ResultsA total of 90 eligible patients were included in the study. There were 30 patients in Group O, 30 patients in Group D, and 30 patients in Group OD. Intraoperative nausea in Group D was more than the other two groups. Postoperative nausea in group OD was lesser than the other two groups. Intraoperative vomiting in Group OD was lesser than the other two groups. There was no statistically significant difference among the groups in postoperative vomiting (P > 0.05).ConclusionCombined use of dexamethasone and ondansetron for the same indication seems to increase the antiemetic efficacy.

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