• Neuroscience · Jan 2003

    Comparative Study

    Effects of testosterone on hippocampal CA1 spine synaptic density in the male rat are inhibited by fimbria/fornix transection.

    • E G Kovacs, N J MacLusky, and C Leranth.
    • Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, FMB 328, New Haven, CT 06520, USA.
    • Neuroscience. 2003 Jan 1; 122 (3): 807-10.

    AbstractThis study investigated the contribution of sub-cortical afferent input to the effects of testosterone (T) on spine synapse density in the CA1 subfield of the hippocampus, in adult male rats. Gonadectomized (GDX) male rats exhibited a considerably lower density of spine synapses in the CA1 region than control, intact males. The effects of GDX were reversed by treatment with testosterone propionate (TP; 500 microg/day, for 2 days). Transection of the fimbria/fornix (FF) had no significant effect on the synaptic density in non-GDX males. However, FF transection partially inhibited the responses to TP in GDX animals. These data suggest that the effects of T on spine synapse density in the CA1 region of the male rat hippocampus are partially, but not completely, dependent on afferent sub-cortical input.

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