• Jordana S Putti, Vanessa K Engers, Fernanda M Heemann, Tiago B Salomon, Mara S Benfato, and Fernanda S Hackenhaar.
• Department of Biophysics, Postgraduate Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
• Nutrition. 2019 Oct 1; 66: 173-179.

ObjectivesThe loss of antioxidant protection from estrogen during menopause may lead to oxidative stress in the kidneys. Thus, antioxidant supplementation may potentially decrease the menopause-derived oxidative stress. The aim of this study was to evaluate the effect of α-lipoic acid (LA) and ω-3 long-chain polyunsaturated fatty acids on the redox profile of the kidneys in the ovariectomized rat model of menopause.MethodsWe assessed oxidative damage markers and antioxidant defenses in the kidneys of ovariectomized rats supplemented with LA, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). Animals received 3 mo of dietary supplementation.ResultsOvariectomy did not increase the levels of the damage markers carbonyl and malondialdehyde. EPA supplementation increased carbonyl and malondialdehyde levels. Ovariectomy increased fumarase activity but did not affect the levels of vitamin C, glutathione, and glutathione S-transferase activity. LA, DHA, and EPA supplementation decreased fumarase activity, but increased the levels of vitamin C, glutathione, and glutathione S-transferase activity. Vitamin E, superoxide dismutase, glutathione peroxidase, and peroxide consumption were not affected by ovariectomy or supplementation.ConclusionsThe results suggest that ovariectomy did not affect the redox profile in the kidneys. LA, DHA, and EPA supplementation increased certain endogenous antioxidants; however, EPA may have a prooxidant effect on the kidneys.Copyright © 2019 Elsevier Inc. All rights reserved.

22 keywords...

hide…