• Rania Ali El-Farrash, Ghada Ibrahim Gad, Hesham Mohammed Abdelkader, Dalia Ahmed Diaael-Dine Salem, and Safaa AbdElaziz Fahmy.
• Department of Pediatrics-Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: rania.elfarrash@med.asu.edu.eg.
• Nutrition. 2019 Oct 1; 66: 187-191.

ObjectivesWithholding postoperative feeding is common in neonates recovering from surgeries for congenital abnormalities of the gastrointestinal tract (GIT), which leads to prolonged exposure to total parenteral nutrition, intestinal atrophy, and feeding intolerance. Because amniotic fluid plays a significant role in fetal gut maturation and development, the aim of this study was to test a hypothesis suggesting that feeding tolerance could be improved in neonates recovering from surgeries for congenital obstructive bowel abnormalities by enteral administration of simulated amniotic fluid-like solution given enterally (SAFE) containing recombinant human granulocyte colony-stimulating factor and erythropoietin.MethodsThis prospective, double-blind, randomized, placebo-controlled trial was conducted with 40 late preterm/term neonates recovering from GIT surgeries. Neonates were randomly divided postoperatively into two groups: 20 neonates received the test solution (SAFE group) and 20 neonates received distilled water (placebo group) with a gestational age range (34.3-40.4 versus 34-40 wk, respectively) and mean gestational age (37.10 ± 1.68 versus 36.90 ± 1.83 wk, respectively). Treatment was started postoperatively and the test solution (or distilled water) was discontinued when daily enteral intake reached 100 mL/kg.ResultsThe study group showed better feeding tolerance as demonstrated as reflected by an earlier achievement of 50, 100, 120, and 150 mL/kg enteral feeding per day with a higher enteral caloric intake on day 7 post SAFE administration and a higher rate of weight gain (P < 0.05 for all).ConclusionEnteral administration of SAFE may improve postoperative feeding tolerance, enteral caloric intake, and weight gain.Copyright © 2019 Elsevier Inc. All rights reserved.

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