• Hussein Nasser Awada, Iben Engelund Luna, Henrik Kehlet, Heidi Raahauge Wede, Susanne Jung Hoevsgaard, and Eske Kvanner Aasvang.
• Section of Surgical Pathophysiology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark; Anesthesiological Department, The Abdominal Centre, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: hussein.nasser.awada@regionh.dk.
• J Clin Anesth. 2019 Nov 1; 57: 80-86.

Study ObjectivePostoperative cognitive dysfunction (POCD) remains a frequent postoperative complication in non-fast-track surgeries, with negative implications for return to daily activities and work. In fast-track total hip and -knee arthroplasty (THA/TKA) an 8-9% incidence of POCD after 3 months has been reported, but without details on specific perioperative risk factors. Thus, we re-investigated the incidence and role of suggested factors for POCD in a well-controlled patient cohort, to guide future preventive interventions.DesignA subanalysis of a prospective study.SettingHospital ward, patients own home.PatientsOne-hundred-and-four patients undergoing elective THA/TKA.InterventionsA full contextual and validated cognitive test battery pre- and 2-3 weeks postoperatively by interview by research nurse.MeasurementsResults from the cognitive test battery were corrected for learning effect by normative data from an age-matched unoperated control group. Potential perioperative risk factors (age, procedure, gender, inflammation, blood-percentage, opioids etc.) associated with POCD was investigated by univariate and multivariate logistic analysis, with a 5% significance level.Main ResultsFour patients (3.9%) developed POCD. POCD-positive patients consumed higher dose of opioids in the acute postoperative period (postoperative days 0-3: median 214 mg), vs. POCD-negative patients (postoperative days 0-3: median 98 mg, p = 0.008), and during the 2-3-week study period (POCD-positive vs. POCD-negative patients, median 739 mg vs. 208 mg, respectively). Other pre and postoperative factors were non-significant but associated with the development of POCD.ConclusionPOCD is rare in fast-track THA/TKA patients and may be related to postoperative opioid consumption, supporting the ongoing focus on opioid-sparing analgesia.Copyright © 2019 Elsevier Inc. All rights reserved.

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