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- Jisheng Wang, Fengming Wu, and Chun Shi.
- Department of Anatomy, Guangzhou Medical University, Guangzhou, Guangdong 510182, China.
- Neuroscience. 2013 Sep 5;247:227-33.
AbstractIncreasing evidence has linked membrane cholesterol to amyloid precursor protein (APP) processing. β-Sitosterol (BS) is one of the most common forms of plant sterols, with the structure very similar to that of cholesterol. Using HT22 mouse hippocampal cells, this study investigated whether the substitution of membrane cholesterol with BS influences APP metabolism. It was found that cholesterol/BS substitution promoted nonamyloidogenic processing of APP without affecting membrane fluidity. Additional experiments suggest that the effect of membrane BS on APP metabolism is associated with the migration of APP from lipid rafts toward non-raft regions. Given that dietary BS can enter the brain and accumulates in the plasma membrane of brain cells, these results suggest a potential use of BS in the prevention of Alzheimer's disease.Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
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