• Neuroscience · Sep 2013

    Pitpnm1 is expressed in hair cells during development but is not required for hearing.

    • F A Carlisle, S Pearson, K P Steel, and M A Lewis.
    • Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, Cambs CB10 1SA, United Kingdom. Electronic address: francesca.carlisle@gmail.com.
    • Neuroscience. 2013 Sep 17; 248: 620-5.

    AbstractDeafness is a genetically complex disorder with many contributing genes still unknown. Here we describe the expression of Pitpnm1 in the inner ear. It is expressed in the inner hair cells of the organ of Corti from late embryonic stages until adulthood, and transiently in the outer hair cells during early postnatal stages. Despite this specific expression, Pitpnm1 null mice showed no hearing defects, possibly due to redundancy with the paralogous genes Pitpnm2 and Pitpnm3. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

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