• Lung Cancer · Apr 2013

    Case Reports

    When a thymic carcinoma "becomes" a GIST.

    • Valentina Rossi, Maddalena Donini, Pietro Sergio, Rodolfo Passalacqua, Giulio Rossi, and Sebastiano Buti.
    • Department of Medical Oncology, Istituti Ospitalieri of Cremona, Italy. valentina.rossi@ircc.it
    • Lung Cancer. 2013 Apr 1; 80 (1): 106-8.

    AbstractThymic carcinoma (TC) is a rare intrathoracic malignancy that it can be invasive and refractory to conventional treatment. Comprehensive genomic analysis evidenced a molecularly distinct subset of thymic carcinoma with high prevalence of c-kit mutation, which may behave as a gastrointestinal stromal tumor (GIST). Here, we present a case report of TC with c-Kit mutation, who has relapsed after exposure to multiple lines of combination chemotherapy, but he has shown an impressive and long lasting response to sunitinib after imatinib failure.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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